Kris Vaddi Selected Research

INCB 16562

4/2010	Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis.
1/2010	INCB16562, a JAK1/2 selective inhibitor, is efficacious against multiple myeloma cells and reverses the protective effects of cytokine and stromal cell support.
11/2009	Combined inhibition of Janus kinase 1/2 for the treatment of JAK2V617F-driven neoplasms: selective effects on mutant cells and improvements in measures of disease severity.

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Kris Vaddi Research Topics

Disease

11	Neoplasms (Cancer) 01/2018 - 06/2006
11	Primary Myelofibrosis (Myelosclerosis) 04/2015 - 11/2009
6	Splenomegaly 04/2015 - 11/2009
4	Thrombocytopenia (Thrombopenia) 01/2016 - 03/2012
3	Hematologic Neoplasms (Hematological Malignancy) 01/2021 - 11/2009
3	Multiple Myeloma 01/2018 - 01/2009
3	Polycythemia Vera 01/2016 - 11/2009
3	Anemia 04/2015 - 03/2012
3	Rheumatoid Arthritis 07/2012 - 10/2007
3	Arthritis (Polyarthritis) 05/2010 - 10/2005
2	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2021 - 01/2018
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2018 - 03/2012
2	Inflammation (Inflammations) 09/2011 - 01/2006
2	Thrombocytosis (Thrombocythemia) 09/2010 - 04/2010
1	Type 2 Diabetes Mellitus (MODY) 01/2022
1	Lymphoma (Lymphomas) 01/2021
1	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2020
1	Acute Promyelocytic Leukemia 01/2020
1	Carcinogenesis 01/2018
1	Headache (Headaches) 01/2016
1	Pruritus (Itching) 01/2016
1	Diarrhea 01/2016
1	Fatigue 01/2016
1	Chronic Myelomonocytic Leukemia (Leukemia, Chronic Myelomonocytic) 01/2016
1	Polycythemia (Erythrocytosis) 01/2016
1	Cachexia 01/2014
1	Weight Loss (Weight Reduction) 11/2011
1	Skin Diseases (Skin Disease) 09/2011
1	Atopic Dermatitis (Atopic Eczema) 09/2011
1	Psoriasis (Pustulosis Palmaris et Plantaris) 09/2011
1	Edema (Dropsy) 09/2011
1	Contact Dermatitis (Eczema, Contact) 09/2011
1	Infections 07/2011
1	Experimental Arthritis 05/2010
1	Autoimmune Diseases (Autoimmune Disease) 05/2010
1	Carcinoma (Carcinomatosis) 02/2010
1	Pancreatic Neoplasms (Pancreatic Cancer) 02/2010
1	Essential Thrombocythemia 11/2009
1	Body Weight (Weight, Body) 11/2009
1	Weight Gain 11/2009
1	Philadelphia Chromosome 11/2009
1	Endotoxemia 10/2007
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 07/2006
1	Breast Neoplasms (Breast Cancer) 06/2006

Drug/Important Bio-Agent (IBA)

12	ruxolitinibIBA 01/2016 - 04/2010
7	CytokinesIBA 09/2011 - 01/2009
6	Janus KinasesIBA 01/2018 - 11/2009
3	Phosphotransferases (Kinase)IBA 01/2018 - 06/2006
3	Pharmaceutical PreparationsIBA 01/2016 - 02/2010
3	Janus Kinase 1IBA 04/2015 - 11/2009
3	INCB 16562IBA 04/2010 - 11/2009
3	LigandsIBA 03/2007 - 01/2006
2	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 01/2006
2	Antineoplastic Agents (Antineoplastics)IBA 01/2018 - 11/2009
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2018 - 01/2018
2	Janus Kinase 2IBA 12/2013 - 09/2010
2	Janus Kinase InhibitorsIBA 05/2013 - 01/2009
2	Interleukin-23 (Interleukin 23)IBA 09/2011 - 05/2010
2	Interleukin-6 (Interleukin 6)IBA 05/2010 - 01/2010
2	Metalloproteases (Metalloproteinases)IBA 03/2007 - 06/2006
2	Trastuzumab (Herceptin)FDA Link 02/2007 - 06/2006
1	INCB 13739IBA 01/2022
1	ChromatinIBA 01/2021
1	Protein-Arginine N-Methyltransferases (Methyltransferase, Protein Arginine)IBA 01/2021
1	Arginine (L-Arginine)FDA Link 01/2021
1	EnzymesIBA 01/2021
1	RetinoidsIBA 01/2020
1	Arsenic Trioxide (Trisenox)FDA Link 01/2020
1	AcidsIBA 01/2020
1	InterferonsIBA 01/2020
1	Bendamustine Hydrochloride FDA Link 01/2018
1	Proteins (Proteins, Gene)FDA Link 01/2018
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2018
1	IsoenzymesIBA 01/2018
1	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2018
1	Hydroxyurea (Hydrea)FDA LinkGeneric 01/2016
1	Methotrexate (Mexate)FDA LinkGeneric 07/2012
1	Antirheumatic Agents (DMARD)IBA 07/2012
1	Thymic Stromal LymphopoietinIBA 09/2011
1	Ustekinumab (CNTO 1275)FDA Link 09/2011
1	Interleukin-12 (IL 12)IBA 09/2011
1	CC ChemokinesIBA 07/2011
1	5- ((4- (4- (2- ethoxy- 5- (trifluoromethyl)- 2,3- dihydro- 1H- inden- 1- yl)- 3- methylpiperazin- 1- yl)- 4- methylpiperidin- 1- yl)carbonyl)- 4,6- dimethylpyrimidineIBA 07/2011
1	baricitinibIBA 05/2010
1	epacadostatIBA 02/2010
1	Tryptophan (L-Tryptophan)FDA Link 02/2010
1	InterleukinsIBA 01/2009
1	CollagenIBA 10/2007
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2007
1	LipopolysaccharidesIBA 10/2007
1	INCB3619IBA 03/2007
1	ErbB Receptors (EGF Receptor)IBA 03/2007
1	Monoclonal AntibodiesIBA 02/2007
1	Epidermal Growth Factor (EGF)IBA 02/2007
1	Gefitinib (Iressa)FDA Link 07/2006
1	Neuregulin-1 (Neuregulin 1)IBA 07/2006
1	Peptide Hydrolases (Proteases)FDA Link 06/2006
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 06/2006

Therapy/Procedure

8	Therapeutics 01/2018 - 03/2007
1	Erythrocyte Transfusion 11/2012